1400 Days on GLP-1…Why I’m Taking My Highest Dose Ever

Day 1403 on Zepbound | After nearly 1,400 days on GLP-1, I’m taking my highest dose yet…and what I noticed on the very first day was a big change. Let’s talk about how it feels and why it means so much to me. Plus….why I’m out of my chair! (:

My Zepbound 10 mg Experience: A New Chapter After Nearly Four Years

Want to know more about today’s video? On day 1,403 of my journey, I’m sharing my Zepbound 10 mg experience for the first time. After nearly four years on tirzepatide, I took a dose I had never taken before—and the next day felt noticeably different.

I’m feeling hopeful. But this update is about more than a medication change. It’s also about opening up when things get difficult, reconnecting with community, and returning to routines that help me feel supported.

Why This Was a Big Step for Me

I started this journey on December 1, 2022, with Mounjaro. Much of my initial weight loss happened while I was taking 2.5 mg, and I reached my goal weight on 5 mg. Over the following years, there were periods when I moved to 7.5 mg.

This time, though, I had been on 7.5 mg for months and was struggling with persistent cravings and frequent snacking. I had regained about 18 pounds, and I knew I needed to be honest about where I was.

Sharing that struggle in the previous video mattered. It gave me a way to reach out instead of keeping everything to myself.

That history describes my individual experience, not a dosing plan for anyone else. The official Zepbound dosing information explains that 2.5 mg is a starting dose, not an approved maintenance dose, and that dosing changes should be managed with your prescribing clinician.

What I Noticed on My First Day

The biggest change in my Zepbound 10 mg experience was how quiet the food chatter felt that first day. I ate my meals without the same constant pull toward more food or snacks.

One small moment stood out while I was running errands. I parked near Crumbl and realized I didn’t feel the familiar urge to go inside. The difference felt significant because those cravings had been taking up so much space in my day.

This was an encouraging first-day observation. It doesn’t tell me everything about how the coming weeks will go, and it doesn’t mean someone else will have the same response or notice changes on the same timeline.

Getting Back to Meals I Enjoy

Along with the medication change, I spent time preparing meals. Having something ready gave me a practical way to follow through on my plans.

For lunch, I made chicken breast with peppers, onions, cilantro rice, mild Rotel, and black beans, with a little adobo seasoning. For dinner, I planned smoked sausage with vegetables, including asparagus, zucchini, squash, onion, and bell peppers.

I also shared the microwave steamer bags I’ve used for years. They’re one way I make vegetables convenient and enjoyable. If you use them, choose bags specifically intended for microwave cooking and follow the package instructions.

In the video, I mention Bright Line Eating because ideas I learned from it still influence how I think about meals. That is part of my history, rather than a meal plan everyone needs to follow. Your own nutritional needs and preferences may look different.

Community Was Part of the Change, Too

I emailed several people in our Amy 2.0 community that day. Reconnecting reminded me why sharing this journey matters so much.

It’s easy to show up when things are going well. Being honest when they aren’t can feel harder, but that was when I needed connection most. Preparing meals and reaching out gave me concrete steps to take alongside this new chapter in treatment.

Making Room for Different Experiences

I also discuss how stories about medication can influence our expectations. My encouraging day is one experience; someone else’s difficult experience deserves to be taken seriously, too.

Zepbound can cause side effects, including serious ones. The official Zepbound safety information is a useful place to learn about risks and warnings. A conversation with your healthcare professional can help you put personal stories into context and discuss what is appropriate for you.

For now, I’m grateful for a hopeful day and for the people walking through this with me. You can explore more videos and conversations at Amy Denae’s Weight Loss Community.

What routines or sources of support have helped you through a new chapter in your journey? I’d love to hear from you in the comments.

This article shares my personal experience and general educational resources. It is not medical advice. Consult your prescribing clinician before changing your medication dose.

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